2010-2012

Lee, C.; Pedrick, E. A.; Leadbeater, N. E. Preparation of Arene Chromium Tricarbonyl Complexes Using Continuous-Flow Processing: (η6-C6H5CH3)Cr(CO)3 as an Example, Journal of Flow Chemistry 20122, 115-117.

Mercadante, M. A.; Leadbeater, N. E. Development of methodologies for reactions involving gases as reagents: microwave heating and conventionally-heated continuous-flow processing as examples, Green Processing and Synthesis 2012, 1, 499-507.

Anderson, N.; Gernaey, K. V.; Jamison, T. F.; Kircher, M.; Wiles, C.; Leadbeater, N. E.; Sandford, G.; Richardson, P. The challenges and benefits of flow chemistry to optimize drug development, Future Medicinal Chemistry 20124, 1779-1789.

Grewal, N. K.; Leadbeater, N. E. The central role of chemistry in ‘quality by design’ approaches to drug development, Future Medicinal Chemistry 20124, 1799-1810.

Kelly, C. B.; Mercadante, M. A.; Hamlin, T. A.; Fletcher, M. H.; Leadbeater, N. E. Oxidation of α-Trifluoromethyl Alcohols Using a Recyclable Oxoammonium Salt, Journal of Organic Chemistry 201277, 8131-8141.

Rudzinkski, D. M.; Kelly, C. B.; Leadbeater, N. E. A Weinreb amide approach to the synthesis of trifluoromethylketones, Chem. Commun. 201248, 9610-9612.

Mercadante, M. A.; Kelly, C. B.; Lee, C.; Leadbeater, N. E. Continuous Flow Hydrogenation Using an On-Demand Gas Delivery Reactor, Organic Process Research and Development 201216, 1064-1068.

Eddy, N. A.; Kelly, C. B.; Mercadante, M. A.; Leadbeater, N. E.; Fenteany, G. Access to Dienophilic Ene-Triketone Synthons by Oxidation of Diketones with an Oxoammonium Salt, Organic Letters 201214, 498-501.

Gorobets, N. Y.; Yermolayev, S. A.; Gurley, T.; Gurinov, A. A.; Tolstoy, P. M.; Shenderovich, I. G.; Leadbeater, N. E. Difference between 1H NMR signals of primary amide protons as a simple spectral index of the amide intramolecular hydrogen bond strength, Journal of Physical Organic Chemistry 201225, 287-295.

Yermolayev, S. A.; Gorobets, N. Y.; Shishkin, O. V.; Shishkina, S. V.; Leadbeater, N. E. Pathways for cyclizations of hydrazine-derived 2-(2-cyanovinyl)-3-oxo-cyclohex-1-ene enolates, Tetrahedron 201167, 2934-2941.

Kelly, C.B.; Lee, C. X.; Leadbeater, N.E. Copper-catalyzed direct preparation of diaryl sulfides from aryl iodides using potassium thiocyanate as a sulfur transfer reagent, Tetrahedron Letters 201152, 4587-4589

Mercadante, M. A.; Leadbeater, N.E. Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously, Organic and Biomolecular Chemistry 20119, 6575-6578.

Kelly, C.B.; Lee, C. X.; Mercadante, M. A.; Leadbeater, N.E. A Continuous-Flow Approach to Palladium-Catalyzed Alkoxycarbonylation Reactions,Organic Process Research & Development 201115, 717-720.

Pedrick, E.A.; Leadbeater, N.E. Preparation of Cisplatin Using Microwave Heating and Continuous-Flow Processing as Tools, Inorganic Chemistry Communications 201114, 481-483.

Kelly, C.B.; Lee, C.; Leadbeater, N.E. An approach for continuous-flow processing of reactions that involve the in situ formation of organic products, Tetrahedron Letters 201152, 263-265.

Leadbeater, N.E. Cross Coupling: When is free really free?, Nature Chemistry20102, 1007-1009.

Mehmood, A.; Leadbeater, N.E. Copper-catalyzed direct preparation of phenols from aryl halides, Catalysis Communications201012, 64-66.

Leadbeater, N.E. In situ reaction monitoring of microwave-mediated reactions using IR spectroscopy, Chemical Communications201046, 6693-6695.

Mehmood, A.; Devine, W.G.; Leadbeater, N.E. Development of Methodologies for Copper-Catalyzed C-O Bond Formation and Direct Cyanation of Aryl Iodides, Topics in Catalysis201053, 1073-1080.

Russo, A.; Leadbeater, N.E.; Lattanzi, A.A. Convenient Methodology for Nitro-Michael Addition of Carbonyl Compounds Catalyzed by L-Proline Using Microwave Heating, Letters in Organic Chemistry20107, 98-102.

DeBlase, C.; Leadbeater, N.E. Ligand-free Cul-catalyzed cyanation of aryl halides using K4[Fe(CN)6] as cyanide source and water as solvent, Tetrahedron201066, 1098-1101.

Schmink, J.R.; Kormos, C.M.; Devine, W.G.; Leadbeater, N.E. Exploring the Scope for Scale-Up of Organic Chemistry Using a Large Batch Microwave Reactor, Organic Process Research and Development201014, 205-214.

Devine, W.G.; Leadbeater, N.E.; Jacob, L.A. Titanium-catalyzed esterification and transesterification reactions facilitated using microwave heating, Future Medicinal Chemistry20102, 225-230.