2011-2015

Hamlin, T.A.; Leadbeater, N.E. Real-time Monitoring of Reactions Performed Using Continuous-flow Processing: The Preparation of 3-Acetylcoumarin as an Example, Journal of Visualized Experiments 2015, e52393

Alexander, K. A.; Paulhus, E. A.; Lazarus, G .M. L.; Leadbeater, N. E. Exploring the Reactivity of a Ruthenium Complex in the Metathesis of Biorenewable Feedstocks to Generate Value-added Chemicals, Journal of Organometallic Chemistry 2015, 812, 74-80

Miller, S. A.; Leadbeater, N. E Direct, Rapid, Solvent-free Conversion of Unactivated Esters to Amides Using Lithium Hydroxide as a Catalyst, RSC Advances 2015, 5, 93248-93251

Hamlin, T. A.; Kelly, C. B.; Ovian, J. M.; Wiles, R. J.; Tilley, L. J.; Leadbeater, N. E. Toward a Unified Mechanism for Oxoammonium Salt-Mediated Oxidation Reactions: A Theoretical and Experimental Study Using a Hydride Transfer Model, Journal of Organic Chemistry 2015, 80, 8150-8167

Negus, M. P.; Mansfield, A. C.; Leadbeater, N. E. The Preparation of Ethyl Levulinate Facilitated by Flow Processing: The Catalyzed and Uncatalyzed Esterification of Levulinic Acid, Journal of Flow Chemistry 2015, 5, 148-150

Marco, M. M.; Leadbeater, N. E. Synthesis of Palladium N-Heterocyclic Carbene Complexes and the Assessment and Implications of the Use of these Complexes as Catalysts for Alkoxycarbonylation Reactions, International Journal of Advanced Research in Chemical Science 2015, 2, 14-20

Kelly, C. B.; Mercadante, M. A.; Carnaghan, E. R.; Doherty, M. J.; Fager, D. C.; Hauck, J. J.; Macinnis, A. E.; Tilley, L. J.; Leadbeater, N. E. Synthesis of Perfluoroalkyl-Substituted Vinylcyclopropanes by Way of Enhanced Neighboring Group Participation, European Journal of Organic Chemistry 2015, 4071-4076

Kelly, C. B.; Ovian, J. M.; Cywar, R. M.; Gossland, T. R.; Wiles, R. J.; Leadbeater, N. E. Oxidative Cleavage of Allyl Ethers by an Oxoammonium Salt, Organic and Biomolecular Chemistry 2015, 13, 4255-4259

Kelly, C. B.; Lambert, K. M.; Mercadante, M. A.; Ovian, J. M.; Bailey, W. F.; Leadbeater, N. E. Access to Nitriles from Aldehydes Mediated by an Oxoammonium Salt, Angewandte Chemie, International Edition 2015, 54, 4241-4245

Leadbeater, N. E.; Bobbitt, J. M. TEMPO-Derived Oxoammonium Salts as Versatile Oxidizing Agents, Aldrichimica Acta 2014, 47, No. 3.

Hamlin, T. A.; Lazarus, G. M. L.; Kelly, C. B.; Leadbeater, N. E. A Continuous-Flow Approach to 3,3,3-Trifluoromethylpropenes: Bringing Together Grignard Addition, Peterson Elimination, Inline Extraction, and Solvent Switching, Organic Process Research and Development 2014, 18, 1253-1258.

Mercadante, M. A.; Kelly, C. B.; Hamlin, T. A.; Delle Chiaie, K. R.; Drago, M. D.; Duffy, K. K.; Dumas, M .T.; Fager, D. C.; Glod, B. L. C.; Hansen, K. E.; Hill, C. R.; Leising, R. M.; Lynes, C. L.; MacInnis, A. E.; McGohey, M. R.; Murray, S. A.; Piquette, M. C.; Roy, S. L.; Smith, R. M.; Sullivan, K. R.; Truong, B. H.; Vailonis, K. M; Gorbatyuk, V.; Leadbeater, N. E.; Tilley L. J. 1,3-γ-Silyl-elimination in electron-deficient cationic systems, Chemical Science 2014, 5, 3983-3994.

Hill, N. J.; Bowman, M. D.; Esselman, B. J.; Byron, S. D.; Kreitinger, Leadbeater, N. E. Ligand-Free Suzuki–Miyaura Coupling Reactions Using an Inexpensive Aqueous Palladium Source: A Synthetic and Computational Exercise for the Undergraduate Organic Chemistry Laboratory, Journal of Chemical Education 2014, 91, 1054-1057.

Leadbeater, N. E. Microwave-Assisted Synthesis: General Concepts, Advances in Polymer Science 2014, 1-44.

Desrosiers, J.-N.; Kelly, C. B.; Fandrick, D. R.; Nummy, L.; Campbell, S. J.; Wei, X.; Sarvestani, M.; Lee, H.; Sienkiewicz, A.; Sanyal, S.; Zeng, X.; Grinberg, N; Ma, S.; Song, J. J.; Senanayake, C. H. A Scalable and Regioselective Synthesis of 2-Difluoromethyl Pyridines from Commodity Chemicals, Organic Letters 2014, 17, 1724-1727.

Leadbeater, N. E. Microwave Heating as a Tool for Organic Chemistry, Comprehensive Organic Synthesis, 2nd Edition 2014, 9, 234-286.

Hamlin, T. A.; Kelly, C. B.; Cywar, R. M.; Leadbeater, N. E. Methylenation of Perfluoroalkyl Ketones using a Peterson Olefination Approach,Journal of Organic Chemistry 2014, 79, 1145-1155.

Bobbitt, J. M.; Bartelson, A. L.; Bailey, W. F.; Hamlin, T. A.; Kelly, C. B. Oxoammonium Salt Oxidations of Alcohols in the Presence of Pyridine Bases, Journal of Organic Chemistry 2014, 79, 1055-1067.

Leadbeater, N. E. Opening an Aladdin’s cave: the Suzuki coupling in a room-temperature ionic liquid, Chemical Communications 2014, 50, 1515-1518.

Stencel, L. M.; Leadbeater, N. E. Application of a new interface for rapid optimisation of bio-catalysed processes: proteolytic digestion and an enzyme-catalysed transesterification as examples, New Journal of Chemistry 2014, 38, 242-247.

Kelly, C. B.; Mercadante, M. A.; Leadbeater, N. E. Trifluoromethyl ketones: properties, preparation, and application, Chemical Communications 2013, 39, 11133-11148.

Hamlin, T. A.; Leadbeater, N. E. Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions, Beilstein Journal of Organic Chemistry 2013, 9, 1843-1852.

Rudzinski, D. M.; Leadbeater, N. E. Microwave heating and conventionally-heated continuous-flow processing as tools for performing cleaner palladium-catalyzed decarboxylative couplings using oxygen as the oxidant – a proof of principle study, Green Processing and Synthesis 2013, 9, 323-328.

Leadbeater, N. E. Microwave Heating and Continuous-Flow Processing as Tools for Metal-Catalyzed Couplings: Palladium-Catalyzed Suzkui-Miyaura, Heck, and Alkoxycarbonylation Reactions, Transition Metal-Catalyzed Couplings in Process Chemistry 2013, 279-298.

Leadbeater, N. E. Approaches to the Scale-Up of Organic Chemistry using Microwave Heating, Scalable Green Chemistry 2013, 301-338.

Kelly, C. B.; Mercadante, M. A.; Wiles, R. J.; Leadbeater, N. E. Oxidative Esterification of Aldehydes Using a Recyclable Oxoammonium Salt,Organic Letters 2013, 15, 2222-2225.

Hamlin, T. A.; Kelly, C. B.; Leadbeater, N. E. Dehydrogenation of Perfluoroalkyl Ketones Using a Recyclable Oxoammonium Salt, European Journal of Organic Chemistry 2013, 3658-3661.

Mercadante, M.; Kelly, C. B.; Bobbitt, J. M.; Tilley, L. J.; Leadbeater, N. E. Synthesis of 4-acetamido-2,2,6,6-tetramethylpiperidine-1-oxoammonium tetrafluoroborate and 4-acetamido-(2,2,6,6-tetramethyl-piperidin-1-yl)oxyl and their use in oxidative reactions, Nat. Protoc. 2013, 8, 666-676.

Kelly, C. B. Synlett Spotlight No. 423 Synlett 2013, 24 , 527-528.

Lee, C.; Pedrick, E. A.; Leadbeater, N. E. Preparation of Arene Chromium Tricarbonyl Complexes Using Continuous-Flow Processing: (η6-C6H5CH3)Cr(CO)3 as an Example, Journal of Flow Chemistry 20122, 115-117.

Mercadante, M. A.; Leadbeater, N. E. Development of methodologies for reactions involving gases as reagents: microwave heating and conventionally-heated continuous-flow processing as examples, Green Processing and Synthesis 2012, 1, 499-507.

Anderson, N.; Gernaey, K. V.; Jamison, T. F.; Kircher, M.; Wiles, C.; Leadbeater, N. E.; Sandford, G.; Richardson, P. The challenges and benefits of flow chemistry to optimize drug development, Future Medicinal Chemistry 20124, 1779-1789.

Grewal, N. K.; Leadbeater, N. E. The central role of chemistry in ‘quality by design’ approaches to drug development, Future Medicinal Chemistry 20124, 1799-1810.

Kelly, C. B.; Mercadante, M. A.; Hamlin, T. A.; Fletcher, M. H.; Leadbeater, N. E. Oxidation of α-Trifluoromethyl Alcohols Using a Recyclable Oxoammonium Salt, Journal of Organic Chemistry 201277, 8131-8141.

Rudzinkski, D. M.; Kelly, C. B.; Leadbeater, N. E. A Weinreb amide approach to the synthesis of trifluoromethylketones, Chem. Commun. 201248, 9610-9612.

Mercadante, M. A.; Kelly, C. B.; Lee, C.; Leadbeater, N. E. Continuous Flow Hydrogenation Using an On-Demand Gas Delivery Reactor, Organic Process Research and Development 201216, 1064-1068.

Eddy, N. A.; Kelly, C. B.; Mercadante, M. A.; Leadbeater, N. E.; Fenteany, G. Access to Dienophilic Ene-Triketone Synthons by Oxidation of Diketones with an Oxoammonium Salt, Organic Letters 201214, 498-501.

Gorobets, N. Y.; Yermolayev, S. A.; Gurley, T.; Gurinov, A. A.; Tolstoy, P. M.; Shenderovich, I. G.; Leadbeater, N. E. Difference between 1H NMR signals of primary amide protons as a simple spectral index of the amide intramolecular hydrogen bond strength, Journal of Physical Organic Chemistry 201225, 287-295.

Yermolayev, S. A.; Gorobets, N. Y.; Shishkin, O. V.; Shishkina, S. V.; Leadbeater, N. E. Pathways for cyclizations of hydrazine-derived 2-(2-cyanovinyl)-3-oxo-cyclohex-1-ene enolates, Tetrahedron 201167, 2934-2941.

Kelly, C.B.; Lee, C. X.; Leadbeater, N.E. Copper-catalyzed direct preparation of diaryl sulfides from aryl iodides using potassium thiocyanate as a sulfur transfer reagent, Tetrahedron Letters 201152, 4587-4589

Mercadante, M. A.; Leadbeater, N.E. Continuous-flow, palladium-catalysed alkoxycarbonylation reactions using a prototype reactor in which it is possible to load gas and heat simultaneously, Organic and Biomolecular Chemistry 20119, 6575-6578.

Kelly, C.B.; Lee, C. X.; Mercadante, M. A.; Leadbeater, N.E. A Continuous-Flow Approach to Palladium-Catalyzed Alkoxycarbonylation Reactions,Organic Process Research & Development 201115, 717-720.

Pedrick, E.A.; Leadbeater, N.E. Preparation of Cisplatin Using Microwave Heating and Continuous-Flow Processing as Tools, Inorganic Chemistry Communications 201114, 481-483.

Kelly, C.B.; Lee, C.; Leadbeater, N.E. An approach for continuous-flow processing of reactions that involve the in situ formation of organic products, Tetrahedron Letters 201152, 263-265.