Leadbeater, N. E.; McGowan, C.B. Laboratory Experiments Using Microwave Heating; CRC Press 2013 Boca Raton FL

ISBN-10: 1439856095

ISBN-13: 978-1439856093


This book presents a series of procedures for organic, inorganic, analytical, and physical chemistry experiments. Each experimental protocol comprises a chapter in the text that is available for purchase individually. Each protocol contains a brief introduction to the concepts behind the chemistry covered, followed by detailed procedures for performing the reaction using a small and a larger microwave unit. The book covers all commonly available scientific microwave apparatus currently used in teaching laboratories. Each chapter concludes with questions for students to answer as part of their laboratory write-up. The experiments are also featured online.

Leadbeater, N.E. Editor Microwave Heating as a Tool for Sustainable Chemistry; CRC Press 2010 Boca Raton FL

ISBN: 978-1439812693


Shorter reaction times, higher product yields, and enhanced selectivity are some of the advantages microwave heating has over conventional methods, causing its use to transition from a curiosity to mainstream, both in industrial and academic settings. Microwave Heating as a Tool for Sustainable Chemistry showcases the application of microwave heating in a number of areas of preparative chemistry as well as in the biosciences. From organic chemistry to materials and biological applications., the book begins with an introduction to microwave heating, the physical concepts behind it, its application in synthetic chemistry, and commercially available microwave equipment. It shows how microwave heating can be used to facilitate the clean and sustainable synthesis of organic compounds. The authors examine microwave heating as a tool for sustainable polymer chemistry, with discussions of the use of alternative solvents and feedstocks, the design of degradable polymeric materials, and recycling polymers. They then discuss the significant contribution made by microwave-promoted synthesis in the drug discovery process, with a focus on how the technology has been used to generate discovery chemistry libraries and as a tool for medicinal chemists. Other topics examined in this application-driven text include the use of microwave heating in the preparation of inorganic and organometallic compounds, in the production of inorganic materials, and in the area of biosciences. The book examines the scale-up of microwave-promoted chemistry and describes the various approaches and the current commercially available microwave reactors available for scale-up. It also discusses microwave heating as a tool for teaching in the undergraduate organic chemistry laboratory. It explores curriculum, the broad range of reactions that can be performed, and the incorporation of green chemistry principles.

Mayo, D.W.; Pike; R.M.; Forbes, D.C. Microscale Organic Laboratory with Multistep and Multiscale Syntheses; 2010 Wiley Hoboken NJ

ISBN: 978-0471215028


This is a laboratory text for the mainstream organic chemistry course taught at both two and four year schools, featuring both microscale experiments and options for scaling up appropriate experiments for use in the macroscale lab. It provides complete coverage of organic laboratory experiments and techniques with a strong emphasis on modern laboratory instrumentation, a sharp focus on safety in the lab, excellent pre- and post-lab exercises, and multi-step experiments. Notable enhancements to this new edition include inquiry-driven experimentation, validation of the purification process,and the implementation of greener processes (including contributions from Drs Cynthia McGowan and Nicholas Leadbeater on use of microwave heating) to perform traditional experimentation..

Leadbeater, N.E.; McGowan, C.B. Fast, Clean Organic Chemistry: Microwave Assisted Laboratory Manual; CEM Corp. 2006 Matthews NC


Expose your students to the most modern synthetic methods and the complex chemistries that they will be using after graduation, including multi-step and multi-component reactions that you are currently unable to teach due to time restrictions! Reactions typically covered in academic organic laboratories require lengthy reflux times and leave little time for characterization, purification or repetition. The authors of Clean, Fast Organic Chemistry have taken many of these experiments and converted them to include microwave-assisted
heating techniques. Microwave energy is fast becoming the method of choice for both
industrial and academic chemists for driving reactions to completion, as it offers the safest, most effective way to increase reaction rates and improve product yields, while promoting green chemistry. Reactions that previously took hours, or even days, to complete can now be performed in minutes. For example, nucleophilic aromatic substitutions, typically
requiring 60-90 minutes reflux in toluene, are complete in less than 10 minutes in aqueous solution with microwave heating. Decreasing reaction times offers teaching opportunities: students have more time for design, optimization, characterization and analysis of reaction processes and products. Additionally, microwave-assisted reactions are often performed in aqueous solutions or neat, minimizing the need for organic solvents, simplifying the work-up process, and providing “green” reaction conditions.